American Cancer Society: "Pine Bark Extract.". Pycnogenol is the registered trademark name for a French formula. 3. , Improves Symptoms Associated With Menopause, A number of women experience physical discomfort due to symptoms of menopause. Dizziness. It also may help regenerate and maintain vitamin C and E levels while also potentially increasing nitric oxide levels, which may relax and protect blood vessels [1]. Most anal fissures heal with home treatment after a few days or weeks. The results showed that the combination of local and systemic applications of Pycnogenol were the best in terms of ulcer healing even though local application of Pycnogenol also speeded up ulcer healing. Pycnogenol may help reduce symptoms of melasma, a form of hyperpigmentation, possibly because it protects against UV rays. In one clinical trial of 156 osteoarthritis patients, pycnogenol reduced pain, stiffness, swelling, and improved joint function after 3 months. One study suggests that Pycnogenol has no effect when given just 3 weeks beforehand, as it possibly requires a lag time to stabilize the immune response [17]. You can find out your systolic blood pressure by looking at the top number of a blood pressure test. It is standardized to contain 65-75% procyanidins, a class of polyphenols and flavonoids like those found in blueberries, wine, grape skin, citrus, and cocoa. Help your body fight the effects of normal aging. It also appeared to improve their attention span, visual motor skills, and concentration. In 1534, a French ship led by the famous explorer Jacques Cartier became stranded in ice near Quebec, Canada. Pycnogenol (100 mg/day) given to 44 older healthy people with high oxidative stress improved cognitive function, attention, mental performance, and reduced oxidative stress after 12 months [21]. A total of 40 patients with retinopathy (damage to the retina part of the eye) from diabetes and other vascular causes were enrolled in one study. Pycnogenol is the US trademarked name for an antioxidant made from Mediterranean tree bark. Various brands of pycnogenol are available. Cigarette smoking increases platelet aggregation. You can learn more about how we ensure our content is accurate and current by reading our. but is for informational and educational purposes alone. According to the lab results of 10 volunteers, a higher Pycnogenol dose (300 mg) may impact these enzymes after just 30 minutes [52]. Discover what the research says about elimination diets, foods to eat, and more. Dr. Eric L. Zielinski is a sought-after natural . Possess Anti-Inflammatory Action. Low-dose Pycnogenol (30 mg/day) may reduce pain in pregnant women, particularly hip, joint, lower back, groin, and calf cramps in the third trimester [71]. However, it's always a good idea to start with a low dose so you can monitor how your body responds. Pycnogenol may reduce glucose levels, but it doesnt appear to increase insulin production or insulin sensitivity. Some risks associated with Pycnogenol include:, Pycnogenol and other maritime tree barks have not been studied as extensively as traditional medicine. Improve cardiovascular health. While the aspirin reduced the risk for cardiovascular disease and colorectal cancer, among other cancers, the risk of gastrointestinal bleeding outweighed those benefits, creating more risks to the body. Learn more about how to get even skin tone. Too much pressure signals that your heart might be working too hard. High levels of both of these are considered risk factors for heart disease. This makes it very hard to set a standard dose. With strict editorial sourcing guidelines, we only link to academic research institutions, reputable media sites and, when research is available, medically peer-reviewed studies. A number of clinical trials suggest that Pycnogenol may lower blood glucose if taken daily for at least 12 weeks. All included participants had subclinical cognitive impairment, which looks like typical brain fog [22]. Another group of men who took just l-arginine didnt improve [66]. Pycnogenol is a standardized supplement formula guaranteed to contain at least 65-75% proanthocyanidins, the active . Results showed that one month of Pycnogenol led to a significant reduction of hyperactivity with improvement in attention and visual-motor coordination and concentration, as compared to no positive effects in the placebo group. Forty patients were treated with either 600 mg chestnut seed extract a day or 360 mg Pycnogenol a day over a period of four weeks. Some research suggests that procyanidins may have antioxidant and anti-inflammatory activity. Once youre sure that you dont have any negative reactions, you may be able to increase your dosage according to the label. Plus, it reduced total and LDL (bad) cholesterol. The outcome showed significant healing when compared to those subjects who were not given any drug or remedy, concluding that Pycnogenol may be an effective remedy for healing of surgery-related lesions. In another study, 45 men with ED were given 1.7 grams of L-arginine a day during the first month, 40 mg Pycnogenol twice daily during the second month, and the dose increased to three 40-mg Pycnogenol doses daily during the third month. 1 Anti-Aging Beverage, An surprisingstudy found that pine bark extract was far better than aspirin at inhibiting smoking-induced clotting, using lower amounts without the bleeding often found when using aspirin. Helps Treat Erectile Dysfunction. Pycnogenol (100 mg/day) supplementation may decrease symptoms of the common cold and speed up recovery, according to a clinical trial of 146 people. This plant extract also shows promise in such far-flung conditions as traumatic brain injury 40,41, skin problems 37, pain syndromes 38,39, and even tinnitus . Pycnogenol accelerates wound healing and reduces scar formation [Abstract]. All of our content is written by scientists and people with a strong science background. ", Natural Medicines Comprehensive Database web site: "Pycnogenol.". Herbal supplements are not regulated by the Food and Drug Administration (FDA), so they may not be up to the same safety standards as medications that have gone through clinical testing and drug trials. Pycnogenol (100 mg/day) improved menopausal symptoms and quality of life in a clinical trial of 35 women after 8 weeks [68]. Pycnogenol French maritime pine bark extract's 4 basic properties. In addition to general healthy eating, some specific vitamins and minerals may help improve ADHD. Pycnogenol is the registered trademark brand name of French maritime pine bark extract. But, as you know, going for the natural approach can make a huge difference in overall health. Learn more. The review found evidence that pine bark extract may: Similar to its neuroprotective benefits, the metabolic benefits of pine bark extract seem to be related to its antioxidant and anti-inflammatory properties. COPD. A study with four groups of 30 patients each were studied: (1) systemic Pycnogenol and local application; (2) local Pycnogenol only; (3) oral Pycnogenol and (4) medications only (control). However, a study of 24 adults with ADHD found that pycnogenol did not improve ADHD symptoms better than placebo. Pycnogenol-treated subjects experienced an improvement in all menopausal symptoms. In 24 people with early eye damage from diabetes, Pycnogenol improved vision, reduced eye swelling, and improved circulation in the eye after 2 months. In the control group, there were five thrombotic events; whereas the Pycnogenol-treated subjects only experienced nonthrombotic, local flare-ups. The study concluded that Pycnogenol can prevent cramps, muscular pain at rest, and pain after/during exercise healthy people or those with diabetes or claudication. $109.99. There have been a variety of health benefits linked to beta glucan, specifically with the beta-1 3d glucan form which has more biological activity than other types of polysaccharides. If possible, try to get pine bark extract from a local supplier, such as a health food store. Talk to your own doctor about Pycnogenol if youre interested in using it for your own health. It decreased concussion symptoms in 42 student-athletes with a history of sports-related concussions after 6 weeks. In mice, luteolin prevented inflammation and allergic response in the lungs and nose by inhibiting inflammatory cytokines: IL-4, IL-5, and IL-1 3 []. One study of 211 found that Pycnogenol may help prevent edema and ankle swelling from long flights [27]. Eighty-six patients were treated either with Pycnogenol at 150 mg or 300 mg daily or the drugs diosmin and hesperidin (Daflon)at 1,000 mg daily for two months. For mild high blood pressure: 200 milligrams daily. Consequently, blood pressure is lowered. Pycnogenol also potentially improved cognitive function in 78 people with mild cognitive impairment. 1. Blood pressure is an important measure of how much blood is pumping from your heart to the rest of your body . As a skin powder, however, you can use it safely for up to six weeks. In another trial, a combination supplement (Pycnogenol 60 mg/day, L-arginine 690 mg/day and aspartic acid 552 mg/day) improved erectile dysfunction and sexual satisfaction in men after 8 weeks. Beta 1-3D Glucan is recognized by cells in the immune system, and can modify your immune system responses. (9), Related:Top 7 Benefits of Green Tea: The No. SelfDecode does not treat, diagnose or cure any conditions, A deficiency can cause issues like anemia, stunted growth, heart problems and neural tube defects. In one study, 10 patients were treated with placebo and 30 patients were treated with Pycnogenol (100 mg twice or three times daily for two months). It also reduced the size of scars. People who use the supplement along with their traditional medication usually take smaller doses than those who only take the supplement. For example, Enzogenol is an extract from a pine that grows in California and Mexico (Pinus radiata) that may have cognitive-enhancing effects. The staff there can often answer any questions you have and give you more information about specific brands. Pycnogenol treatment lowered the ACE-inhibitor dose required to control blood pressure, and lowered fasting glucose levels as well. Lets begin with asthma. If a blood clot blocks the normal blood flow, it is known as thrombosis. Several studies show how Pycnogenol helps block platelet formation and thus helps prevent thrombosis. In another study, 61 children with ADHD were given one mg per kg/day of Pycnogenol or placebo over four weeks. A review was conducted of French maritimepine bark extract, specifically using the nutritional supplement Pycnogenol. We are dedicated to providing the most scientifically valid, unbiased, and comprehensive information on any given topic. You can refer to the National Institutes of Healths dosage guidelines for specific conditions. There were 88 in the control group and 81 in the Pycnogenol group. In a study of 76 people with allergic asthma, Pycnogenol (100 mg/day) added to conventional corticosteroid inhalers for 6 months helped 55% of them reduce inhaler use frequency and dosage. Still, more research is needed to better understand these findings and pine bark extracts role in reducing damage from head trauma. In 7 volunteers, Pycnogenol (300 mg) for 5 days may reduce the activity of a crucial inflammatory gene (NF-B) [53]. Pycnogenol has given indications that it might be able to benefit heart and artery health, to include reducing high blood pressure. Boost gastrointestinal health. Side Effects of Pycnogenol. . In 19 smokers, increased platelet aggregation was more significantly reduced by 200 mg than either 10 mg or 100 mg of Pycnogenol. The remaining compounds are phenolic acids, which may also have antioxidant activity [1, 2]. Add to Cart. Pycnogenol may stimulate the immune system. A study of 30 women found that Pycnogenol (75 mg/day) may reduce the skin area affected by melasma as well as lower symptoms of fatigue, constipation, body pain, and anxiety [62]. Learn about all the potential benefits of Pycnogenol and find out which ones are most supported by science. This nerve affects our balance and hearing by sending signals to the brain. If you take any medications regularly, talk to your doctor before you start using pycnogenol supplements. The following purported benefits of Pycnogenol are only supported by limited, low-quality clinical studies. Researchers from the study suggest that low Pycnogenol dosage and short study duration may explain the lack of benefits [44]. As I mentioned, pine bark extract is superior when it comes to antioxidants. The U.S. Food and Drug Administration (FDA) does regulate dietary supplements; however, it treats them like foods rather than medications. Certain studies used combination products, so its unknown what the contribution of Pycnogenol itself was. In clinical research, doses up to about 300 mg/day have been used for up to one year without major safety concerns [33, 37]. According to researchers, it may help prevent the rise in free radicals typically seen after exercise, which could cause muscle fatigue and damage [9]. Various studies, referenced at uofmhealth.org, have shown that a daily dosage of Pycnogenol . after four weeks of treatment, Pycnogenol-treated patients showed definite evidence of improved in small blood vessel functions and circulation as compared to those not treated. However, it is also important to see beyond the pyncogenol marketing campaign and understand the possible dangers associated with this natural supplement. There havent been enough studies yet to change practice protocols for treating children. A randomized clinical trial of 30 people found that Pycnogenol (150 mg/day) may help heal vein ulcers from surgery and reduce swelling after 3 months of treatment [25]. Pycnogenol treatment led to significantly better improvement in the lung function and asthma symptoms. $31.99. Typical doses range from 50 milligrams to 450 milligrams per day. Note that each number in parentheses [1, 2, 3, etc.] View as: Grid List. Note that the numbers in parentheses (1, 2, etc.) In a study of 61 ADHD children, pycnogenol reduced hyperactivity, improved attention, and motorics after 1 month. They could interact with medicines to suppress the immune system, chemotherapy drugs, and blood thinners. Research into Pycnogenol has revealed some promising results in over 30 health conditions. Benefits, Nutrition, Uses & How It Compares vs. Blackberries. We believe that the most accurate information is found directly in the scientific source. Seems like it must be pretty amazing, but lets look closer. Skin irritation. It can also be found as creams, lotions or ointments, typically containing 0.5 percent to 2 percent pine bark extract. Another study of 47 women found that supplementing with 30 mg Pycnogenol twice daily for over 1 month may reduce menstrual pain [73]. This article is based on scientific evidence, written by experts and fact checked by our trained editorial staff. Proper nutrition is essential for ADHD treatment. Information is shared for educational purposes only. The extract has been widely studied for the past 40 . Jonathan Ritter, PharmD, PhD (Pharmacology), Small molecule antioxidants (phenolic acids, catechin, and taxifolin) are quickly absorbed and begin to act in the body within 30 min, The remaining more complex antioxidants (long chains of procyanidins) reach the gut, where your, The microbiome-produced active compounds appear in blood 6 h later and remain for at least 14 h, Pycnogenol is standardized to contain 70 5% procyanidins, which should be on the label, Pycnogenol standardization doesnt determine other major active compounds, which can vary. A clinical trial of 57 ADHD children found that daily Pycnogenol (1 mg/kg) for one month may reduce hyperactivity symptoms. The researchers of the study propose that pycnogenol may reduce pain and cramps during retraining and rehabilitation in people with blood vessel problems [11]. Last medically reviewed on January 24, 2018. You should also avoid using pine bark extract without talking to your doctor first if you: You should also do additional research or talk to your doctor before taking pine bark extract if you also take: While pine bark extract is a natural supplement, it can have powerful effects on your health, both positive and negative. Pycnogenol reduced foot swelling in 79% of the patients, versus one percent in the placebo group. Diabetes-associated small blood vessel changes is the leading cause of diabetic ulcers. She loves communicating science and empowering people to achieve their optimal health. . 2005 - 2023 WebMD LLC. The study participants symptoms started to return a month after they stopped taking pine bark extract. (2017). Erectile dysfunction has increased over the past decade or two, creating a pathway for various medications to land on the shelves of numerous medicine cabinets. It also seems to help with cell regeneration and replication. A study of 50 mildly infertile men found that a combination of L-arginine, L-citrulline, roburins, and Pycnogenol (Prelox R) may improve sperm quality, volume, and concentration [75]. Blazs G, et al. WebMD does not provide medical advice, diagnosis or treatment. In a good-quality study, 100 patients with osteoarthritis of the knee were treated for three months either with 150 mg of Pycnogenol a day or placebo. This article reviews tongkat ali, Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. Organika Pycnogenol 50mg 100 Tablets. Our science team is put through the strictest vetting process in the health industry and we often reject applicants who have written articles for many of the largest health websites that are deemed trustworthy. Remember to speak with a doctor before taking Pycnogenol. This article explains which supplements are believed to be safe during pregnancy and which ones you should avoid. It also provides powerful antioxidant protection and helps inhibit inflammatory factors to support. Pycnogenol was gradually increased to 120 mg/day over this time period, while the l-arginine was maintained at 1.7 g/day throughout. Pycnogenol can help control blood pressure, which helps improve overall heart health. It may cause side effects such as: Risks. In theory, pine bark may lower blood pressure and blood sugar level, and these effects have also been reported in some RCTs. Pycnogenol is officially extracted from the French maritime pine (Pinus pinaster), which grows in the southwest coast of France. Results failed to show any efficacy of Pycnogenol or methylphenidate when compared to placebo. The women taking Pycnogenol also experienced improvement in fatigue, sleep, concentration, memory, dizziness, and mood, including less irritability. Moreover, Pycnogenol treatment reduced the use of painkillers. There is currently insufficient evidence to determine what a safe and effective dose of lysine is for specific conditions. Early research shows that taking it at least 5 weeks before the start of allergy season seems to lessen symptoms. Pycnogenol has four main components that contribute to its benefits for men's health. However, these studies appear to be methodologically sound and reliable, with no blatant errors in the study design and data collection. When pycnogenol cream was added to oral supplements in a small study of 18 people with vein ulcers, it helped ulcers heal more quickly [26]. In addition to OPC, grape seed extract contains linoleic acid, flavonoids and phenolic procyanidins that help protect and strengthen capillaries, blood vessels, veins and arteries, which can then improve blood circulation. Our goal is to not have a single piece of inaccurate information on this website. Its been noted that taking OPCs and vitamin C supplements at the same time could increase blood pressure if you have hypertension. Eye health. Since components of Pycnogenol can be modified during digestion and absorption as well as by the liver, diseases that affect the gut or liver may increase or decrease its effects [84]. ( 1) 2. The same study showed that a single, 200-mg Pycnogenol dose remained effective over six days in preventing cigarette-induced enhanced platelet aggregation. Another clinical trial of 76 people with allergic asthma also suggests that Pycnogenol may reduce IgE antibodies and asthma symptoms [18, 16]. Prenatal nutrition can be confusing. Let us discuss them in detail below. But did you know that pine bark extract, like pine oil, is one of natures super antioxidants? Neuroprotective effect of Pycnogenol® following traumatic brain injury. Quality and active ingredients in supplements may vary widely from maker to maker. 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